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Prodrug esters of the indolocarbazole CEP-751 (KT-6587)
R L Hudkins1, M Iqbal, C H Park
1Department of Chemistry, Cephalon, Inc., West Chester, PA 19380, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Prodrug esters of the indolocarbazole CEP-751 (KT-6587) were prepared with the goal of identifying water soluble, stable but cleavable forms for intravenous dosing. A dipeptide proform Lys-beta-Ala (16, CEP-2563/KT-8391) was identified for advancement to clinical trials.