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Efficient synthesis of 3'-glycosylated LacNAc-based oligosaccharides
Y Ding1, M Fukuda, O Hindsgaul
1Burnham Institute, La Jolla Cancer Research Center, CA 92037, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
LacNAc-based oligosaccharides, including sialyl-(2-->3)-LacNAc, dimeric sialyl-(2-->3)-LacNAc, trimeric sialyl-(2-->3)-LacNAc, beta-glucuronyl-(1-->3)-LacNAc, and 3-sulfo-beta-glucuronyl-(1-->3)-LacNAc, were synthesized efficiently from a single protected LacNAc derivative having both OH-3' and 4' unprotected.