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[3H]LY341495, a highly potent, selective and novel radioligand for labeling Group II metabotropic glutamate receptors
P L Ornstein1, M B Arnold, T J Bleisch
1Lilly Research Laboratories, Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285-0510, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
We report herein the synthesis and pharmacological characterization of a tritiated version of the potent and selective cyclopropyl amino acid LY341495 as a radioligand to label group II metabotropic glutamate receptors in rat brain homogenates.