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SAR studies of diaryltriazoles against bacterial two-component regulatory systems and their antibacterial activities
1R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A series of diaryltriazole analogs was discovered to inhibit bacterial two-component regulatory systems in our primary assays, KinA/Spo0F and NRII/NRI. They also showed inhibitory activity in whole cell mechanism-based assays, and they possessed potent activities against several strains of Gram-positive pathogenic bacteria in the standard MIC broth assay.