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Novel angucycline compound with both antigastrin- and gastric mucosal protective-activities
S Uesato1, T Tokunaga, K Takeuchi
1Department of Biotechnology, Faculty of Engineering, Kansai University, Osaka, Japan.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
An angucycline series compound P371 A1 (1) from Streptomyces sp. P371 was established to have a novel structure comprising an ureido group at one of four sugar units on the basis of 2D NMR techniques. 1 exhibited an inhibitory activity against the pentagastrin-stimulated acid secretion as well as protective activities against HCl/ethanol- and indomethacin-induced gastric lesions.