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Actinomycin D, C2 and VII, inhibitors of Grb2-SHC interaction produced by Streptomyces
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Actinomycin D, C2 and VII, cyclic peptides, inhibited Grb2 SH2 domain association (IC50 5-7 microM) with a phosphotyrosine containing peptide derived from the Shc protein (pTyr317). Actinomycins are the first examples of nonphosphorylated natural ligands of SH2 domain.