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Reaction of guanosine with glucose under oxidative conditions
1Institut für Pharmazie und Lebensmittelchemie der Universität München, Germany.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Incubation of glucose with guanosine under oxidative conditions at 37 degrees C or 70 degrees C leads to the formation of a main product, which can be detected by HPLC/DAD. The compound was isolated and identified as N2-carboxymethyl-guanosine (CMG). To confirm the structure, CMG was also synthesized from glyoxal and guanosine.