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Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists
D J Wustrow1, T Capiris, R Rubin
1Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A series of 3-phenylpyrazolo[1,5-a]pyrimidines was prepared and found to have affinity for the human CRF-1 receptor. The 3-dimensional structure of one of the most potent analogs in this series, 10d, was determined by X-ray crystallography and suggests the spatial requirements for potent CRF-1 receptor binding affinity in this series.