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Updated: Aug 6, 2026
Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
Published on: July 25, 2013
Design and synthesis of conformationally-constrained MMP inhibitors
M G Natchus1, M Cheng, C T Wahl
1Procter and Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA.
Abstract:
A novel series of conformationally constrained matrix metalloprotease inhibitors was identified. The potencies observed for these inhibitors were highly dependent upon the substitution pattern on the caprolactam ring as well as the succinate moiety.
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