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Biological properties of synthetic glycoconjugate mimics of heparin comprising different molecular spacers
C M Dreef-Tromp1, J E Basten, M A Broekhoven
1N.V. Organon Scientific Development Group, Oss, The Netherlands.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
The in vitro antithrombotic activity of synthetic glycoconjugates I and II, comprising a flexible polyethylene glycol type and a rigid polyglucose type spacer, respectively, are compared to heparin.