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Updated: Aug 12, 2026

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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
Published on: July 25, 2013
The design, synthesis, and structure-activity relationships of a series of macrocyclic MMP inhibitors
D H Steinman1, M L Curtin, R B Garland
1Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A series of succinate-derived hydroxamic acids incorporating a macrocyclic ring were designed, synthesized, and evaluated as inhibitors of matrix metalloproteinases. The inhibitors were designed based on the published X-ray crystal structure of batimastat (1) complexed with human neutrophil collagenase (MMP-8). The synthesized compounds were shown to inhibit selected MMPs in vitro with low nanomolar potency.

