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Identification of N2-(1-carboxymethyl)guanine (CMG) as a guanine advanced glycation end product
Y al-Abed1, E Schleicher, W Voelter
1Picower Institute for Medical Research, Manhasset, NY 11030, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
The reaction of D-glucose with 9-methylguanine produces N2-fructosyl-9-methylguanine, which undergoes oxidation to produce N2-(1-carboxymethyl)-9-methylguanine as a major adduct.