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Enantioselective synthesis and pharmacology of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC
J Liddle1, J W Huffman, J L Wiley
1Department of Chemistry, Clemson University, SC 29634-1905, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
An enantioselective synthesis of the (1'S,2'R)-dimethylheptyl cannabinoid side chain has been developed and employed in the synthesis of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC (3). Pharmacology, in vivo and in vitro, indicate (3) to be one of the most potent traditional cannabinoids known.