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Updated: Aug 10, 2026

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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
Combinatorial chemistry: from peptides and peptidomimetics to small organic and heterocyclic compounds
A Nefzi1, C Dooley, J M Ostresh
1Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Modified dipeptides have been used successfully for the generation of a variety of small organic and heterocyclic combinatorial libraries, including linear urea, polyamine, hydantoin, thiohydantoin, cyclic urea, cyclic thiourea and bicyclic guanidine. The synthesis and screening results for a number of these libraries are described. The solid phase synthesis of heterocyclic compounds such as diazepine and thiomorpholinone are also described.

