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Synthesis of sialyl Lewis X mimetics using the Ugi four-component reaction
C Y Tsai1, W K Park, G Weitz-Schmidt
1Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Application of the Ugi four-component condensation to rapidly synthesize a library of glycopeptide mimics of the tetrasaccharide SLe(x) as inhibitors of E- and P-selectin, and to study the effect of varied functionality in mimics on the inhibition is described.