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Chemically-tagged Mitsunobu reagents for use in solution-phase chemical library synthesis
G W Starkey1, J J Parlow, D L Flynn
1Parallel Medicinal and Combinatorial Chemistry Unit, Searle Discovery Research Monsanto Life Sciences Company-U2E, Saint Louis, MO 63167, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A general method for high-throughput product purification of Mitsunobu reactions is described. Tagged phosphine and azodicarboxylate reagents are used to synthesize individual library members in solution-phase. Workup and purification are easily accomplished by post-reaction sequestration of the tagged reagents and reagent byproducts by a complementary functionalized ion exchange resin. The reagents are utilized in a 3 step library synthesis.