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Construction of a family of biphenyl combinatorial libraries: structure-activity studies utilizing libraries of
B R Neustadt1, E M Smith, N Lindo
1Schering-Plough Research Institute, Kenilworth, NJ 07033-0539, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A set of biphenyl aminoacid building blocks has been synthesized. These were used to construct partially-peptidic combinatorial libraries as equimolar multi-component samples. Activity of members of this library as vitronectin receptor antagonists is described, together with SAR studies of the most active members. These studies illustrate several important features of combinatorial libraries.