Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A photoactivated prodrug

Y Wei1, Y Yan, D Pei

  • 1Department of Chemistry, Ohio State University, Columbus 43210, USA.

Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of molecular driver mutations in recurrence of early-stage laryngeal cancer following narrow field definitive radiotherapy.

Oral oncology reports·2026
Same author

Genetic markers for primary open-angle glaucoma using next-generation sequencing: abridged secondary publication.

Hong Kong medical journal = Xianggang yi xue za zhi·2025
Same author

Microwave vacuum drying of low-moisture part-skim mozzarella: Process parameters and sample geometry affect product characteristics.

Journal of dairy science·2025
Same author

Band-selective Holstein polaron in Luttinger liquid material A<sub>0.3</sub>MoO<sub>3</sub> (A = K, Rb).

Nature communications·2021
Same author

Study on the regulation mechanism of lipopolysaccharide on oxidative stress and lipid metabolism of bovine mammary epithelial cells.

Physiological research·2021
Same author

Endophytic Bacillus subtilis P10 from Prunus cerasifera as a biocontrol agent against tomato Verticillium wilt.

Brazilian journal of biology = Revista brasleira de biologia·2021
Same journal

Discovery of a potent sGC stimulator with once-daily dosing potential for the treatment of hypertension.

Bioorganic & medicinal chemistry letters·2026
Same journal

OracleScreen-LILRB4 (HTS-Oracle v3): machine learning-guided discovery of myeloid immune checkpoint binders validated in patient-derived cells.

Bioorganic & medicinal chemistry letters·2026
Same journal

Rational design and N-terminal acylation of a lactam-cyclized 11-residue antimicrobial peptide for improved antibacterial potency.

Bioorganic & medicinal chemistry letters·2026
Same journal

Rational design, synthesis, and biological evaluation of chalcone hybrids including benzoylpiperazin (phenylacetylpiperazin)-thiophene as anti- Alzheimer's agents.

Bioorganic & medicinal chemistry letters·2026
Same journal

New aminopiperidine-azoles as antifungal agents against Candida albicans with mechanistic insights into the cAMP-PKA pathway.

Bioorganic & medicinal chemistry letters·2026
Same journal

Novel 1H-pyrrole-2,5-dione derivatives as potential anti-diabetic agents: design, synthesis, in vitro, in ovo, and molecular docking studies.

Bioorganic & medicinal chemistry letters·2026
See all related articles

A novel photolabile prodrug of 5-fluorodeoxyuridine was synthesized. Upon UV light exposure, it releases the active anticancer drug, demonstrating potent cell growth inhibition.

Area of Science:

  • Medicinal Chemistry
  • Photochemistry
  • Cancer Therapeutics

Background:

  • 5-fluorodeoxyuridine (2) is an established anticancer agent.
  • Prodrug strategies can enhance drug delivery and reduce toxicity.
  • Photolabile prodrugs offer spatiotemporal control over drug release.

Purpose of the Study:

  • To design and synthesize a photolabile prodrug of 5-fluorodeoxyuridine (1).
  • To evaluate the photolytic release of the parent drug.
  • To assess the cytotoxicity of the prodrug upon irradiation.

Main Methods:

  • Synthesis of a photolabile derivative (1) of 5-fluorodeoxyuridine (2).
  • Photolysis experiments using long-wavelength UV light (lambda = 350 nm).
  • Cell viability assays to determine cytotoxicity.

Related Experiment Videos

Main Results:

  • Compound 1 was successfully synthesized as a model prodrug.
  • Photolysis of 1 rapidly released 5-fluorodeoxyuridine (2) in solution.
  • Compound 1 alone showed no toxicity, but combined with UV irradiation, it potently inhibited cell growth.

Conclusions:

  • The developed photolabile prodrug enables controlled release of 5-fluorodeoxyuridine.
  • This approach offers a promising strategy for targeted cancer therapy.
  • Photodynamic activation of the prodrug leads to significant anticancer activity.