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Design of novel tripeptides with macrophage migration-enhancing activity
K Nunami1, M Yamada, R Shimizu
1Medicinal Chemistry Research Laboratory, Discovery Research Laboratories, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A new approach to the generation of biologically active peptides from non-peptide lead was demonstrated. C,N-termini protected Phe-Phe-His derivatives possessing macrophage migration-enhancing activity were designed on the basis of the structure of imidazoline derivative 1, and these structure-activity relationships were also described.