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New antifungals selected by molecular topology
L Pastor1, R García-Domenech, J Gálvez
1Unidad de Investigación de Diseño de Fármacos, Facultad de Farmacia, Universitat de Valencia, Spain.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Molecular topology has been applied to find the new lead antimycotic compounds. Among the selected compounds stands out 3,3'-(4,4'-Biphenylene)bis(2,5-diphenyl-2H-tetrazolium chloride), Benztropine mesylate and Dicyclopentamethylenethiuram disulphide, with minimum inhibitory concentrations between 1.6 and 2 micrograms/mL.