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Novel protein kinase C inhibitors: alpha-terthiophene derivatives
D S Kim1, C L Ashendel, Q Zhou
1Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907-1333, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A series of alpha-terthiophene derivatives were prepared and their protein kinase C inhibitory activity were evaluated. The aldehyde derivatives were most potent inhibitors (IC50 < 1 microM). alpha-Terthiophene monoaldehyde was inactive in the inhibitions of protein kinase A, mitogen activated protein kinase and protein tyrosine kinase.