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Synthesis and immunosuppressant activity of pyrazole carboxamides
1Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064-3500, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A series of novel pyrazole carboxamides is disclosed that demonstrate strong immunosuppressant activity in rodent and human mixed leukocyte response (MLR) assays (IC50 < 1 microM). The synthesis, biological activity, mode of action, and pharmacokinetic properties of this new lead series are discussed.