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Synthesis and antibacterial activity of 2-alkoxy penems
1Schering-Plough Research Institute, Kenilworth, New Jersey 07033-0539, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
The phosphite mediated Oxalimide cyclization reaction was extended to 4-dithiocarbonates of N-oxalyl-2-azetidinones to synthesize 2-alkoxy penems 3. In general, the in vitro antibacterial potency of compounds 3 was weak compared to the highly potent 2-alkylthiopenems 2.