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Pyrrolnitrin and related pyrroles endowed with antibacterial activities against Mycobacterium tuberculosis
R Di Santo1, R Costi, M Artico
1Dipartimento di Studi Farmaceutici, Università di Roma La Sapienza, Italy.
Abstract:
During development of nitroheterocycles with potential antimycobacterial activities we have tested against Mycobacterium tuberculosis a number of pyrroles strictly related to pyrrolnitrin, an antifungal antibiotic isolated from Streptomyces pyrrocinia. Some of the tested arylpyrrole derivatives and pyrrolnitrin have shown appreciable inhibiting activity against M. tuberculosis and M. avium. SAR studies well correlate antimycobacterial potency with the presence of halogens in the phenyl ring and a nitro group at position 3 of pyrrole.
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