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Conformationally constrained NO synthase inhibitors: rigid analogs of L-N-iminoethylornithine
1Laboratoire de Synthèse Organique et Chimie Microbienne associé au CNRS, Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, France. j.eustache@univ-mulhouse.fr
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
The synthesis of eight rigid analogs of L-N-iminoethylornithine (L-NIO) is described. The compounds have been evaluated for their inhibition of inducible nitric oxide synthase. Preliminary structure-activity relationships are discussed.