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Synthesis of C-ring aromatic taxoids and evaluation of their multi-drug resistance reversing activity
K Morihira1, T Nishimori, H Kusama
1Department of Chemistry, Tokyo Institute of Technology, Japan.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
The C-aromatic taxoids were synthesized to develop effective inhibitors against drug efflux mediated by p-glycoproteins. Among those tested using multi-drug resistant tumor cells (2780AD), the benzoate 11 exhibited significant activity as potent as verapamil, a well-established MDR reversing agent.