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Synthesis and evaluation of artificial taxoids with antitumor and multi-drug resistance reversing activities
K Morihira1, T Nishimori, H Kusama
1Department of Chemistry, Tokyo Institute of Technology, Japan.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Artificial taxoids were synthesized and subjected to evaluation of their ability of multi-drug resistance reversing and antitumor activities. While the taxoid 4 could not increase cellular accumulation of vincristine in multi-drug resistant tumor cells, the C4-hydroxy analog 15 showed significant effect. However, these compounds showed weak activities on growth inhibition of cancer cells.