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The synthesis of a new type of anthracene DNA intercalator
R Ostaszewski1, E Wilczyńska, M Wolszczak
1Institute of Organic Chemistry, Polish Academy of Sciences, Warszawa. RYSZA@ICHF.EDU.PL
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A new type of DNA intercalator based on anthracene 3 was synthesized. Preliminary binding studies show high affinity of this probe to CT-DNA. Higher binding constant of this compound (4.0 x 10(4) M-1) as compared with that known for 9-aminomethylanthracene, is caused presumably by enhanced electrostatic interaction.