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Rational design of a new series of mixed anti-HIV pronucleotides
N Schlienger1, T Beltran, C Périgaud
1Laboratoire de Chimie Bioorganique, U.M.R. C.N.R.S. 5625, Université Montpellier II, France.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
MonoSATE aryl phosphotriesters of AZT are able to deliver intracellularly the corresponding 5'-mononucleotide. This process requires activation by an esterase followed by a phosphodiesterase. This finding opens the way to the design of new pronucleotide series.