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Triple helix stabilization properties of oligonucleotides containing 8-amino-2'-deoxyguanosine
R Güimil García1, A Bachi, R Eritja
1European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Analysis of the Hoogsteen base pairs of guanine and 8-aminoguanine with cytosine in the gase phase shows a strong stabilization of the 8-aminoguanine.cytosine base pair due to the formation of an extra H-bond. Melting profiles of oligonucleotides carrying 8-amino-2'-deoxyguanosine confirm the triple helix stabilization properties of 8-aminoguanine.