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Synthesis and hybridization property of an oligonucleotide analog containing a 1',3'-di-O-methylene-alpha-D-fructose
1Gilead Sciences, Inc., Foster City, CA 94404, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Hydrogen phosphonate monomers of T (thymine) and C(m) (5-methylcytosine) bearing a 1',3'-di-O-methylene-alpha-D-fructose sugar moiety were synthesized and incorporated into an oligonucleotide. Hybridization studies by thermal denaturation experiment indicated that this oligonucleotide did not form a duplex with the complementary RNA target.