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New phthalimide derivatives with potent analgesic activity: II
R Antunes1, H Batista, R M Srivastava
1Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, PE, Brazil.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Seven new phthalimide derivatives (9a-g) with 1,2,4-oxadiazol-5-yl methyl group attached to nitrogen have been synthesized from N-phthaloylglycine 6 and arylamidoximes 7a-g. All of these showed potent analgesic effect with acetic acid induced "writhing" test in mice. One of the better compounds (ID50 = 2.2 mg/Kg i.p.) has been found to be 9a which also demonstrates analgesic activity against inflammatory pain.