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Synthesis and evaluation of paclitaxel C7 derivatives: solution phase synthesis of combinatorial libraries
1Department of Medicinal Chemistry, Higuchi Bioscience Center, University of Kansas, Lawrence 66045, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A novel and efficient two-step, automated solution phase synthesis of a 26-membered combinatorial chemistry library of paclitaxel C7 esters was accomplished using the HP 7686 Solution Phase Synthesizer. Results of combinatorial synthesis, purification, analysis, and biological evaluation are described.

