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Resveratrol as a new type of DNA-cleaving agent
1Division of Organic Chemsitry, National Institute of Health Sciences, Tokyo, Japan.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
The first demonstration of DNA cleavage by resveratrol '3,5,4'-trihydroxy-trans-stilbene' is presented. Resveratrol mediated relaxation of pBR322 at micromolar concentrations in the presence of Cu2+. Evidence is provided that resveratrol is capable of binding to DNA, and that the Cu(2+)-dependent DNA damage is more likely caused by a copper-peroxide complex rather than by a freely diffusible oxygen species.