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The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis
Published on: March 17, 2010
Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and
C D Carroll1, T O Johnson, S Tao
1Department of Biology, Pharmacopeia, Inc., Princeton, NJ 08543, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A structure-based 18,900-member combinatorial library was synthesized containing a statine template and three cyclic diamino acids as potential P1, P2-P4 surrogates. Evaluation of this encoded library against two aspartyl proteases, plasmepsin II and cathepsin D, led to the identification of selective inhibitors for each enzyme.
