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Efficient construction of 6-azasteroids: dual inhibitors of steroidal 5 alpha-reductase
1Chemical Development Department, Glaxo Wellcome Inc., Research Triangle Park, North Carolina 27709, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A new route to 17 beta-substituted-6-azaandrost-4-en-3-ones, potent dual inhibitors of type 1 and 2 steroidal 5 alpha-reductase, is described.