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Potent inhibitors of the MAP kinase p38
J R Henry1, K C Rupert, J H Dodd
1R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-alpha and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.