Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of
1Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492-7660, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A series of lysosomal protease-sensitive peptides attached to doxorubicin (DOX) was prepared as model substrates for internalizing anticancer immunoconjugates and potential antimetastasis prodrugs. Rates of cathepsin B-mediated release of free drug was measured for each, and human plasma stabilities for representative examples.


