Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Factor concentrates for haemophilia in the developing world

A Bird1, P Isarangkura, D Almagro

  • 1West Province Blood Transfusion Service, Cape Town, South Africa.

Haemophilia : the Official Journal of the World Federation of Hemophilia
|January 5, 1999
PubMed
Summary

Local production of affordable factor concentrates significantly improves hemophilia care in developing nations. This approach enhances accessibility and enables home therapy, benefiting many patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Provenance of late Pleistocene loess in central and eastern Europe: isotopic evidence for dominant local sediment sources.

Scientific reports·2025
Same author

Using morphometrics to identify sex in the eastern blue-tongued skink (Tiliqua scincoides).

Australian veterinary journal·2023
Same author

Blood product utilisation for coronary artery bypass graft surgery at a public and a private hospital in Western Cape Province, South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2021
Same author

Correction: Comparison of the Non-VKA Oral Anticoagulants Apixaban, Dabigatran, and Rivaroxaban in the Extended Treatment and Prevention of Venous Thromboembolism: Systematic Review and Network Meta-Analysis.

PloS one·2016
Same author

Comparison of the Non-VKA Oral Anticoagulants Apixaban, Dabigatran, and Rivaroxaban in the Extended Treatment and Prevention of Venous Thromboembolism: Systematic Review and Network Meta-Analysis.

PloS one·2016
Same author

Haemostatic Abnormalities in Patients with a Clinical Predisposition to Venous Thromboembolism.

Hematology (Amsterdam, Netherlands)·2016

Area of Science:

  • Hematology
  • Public Health
  • Biotechnology

Background:

  • Hemophilia management has advanced due to safe factor concentrates.
  • High costs limit access to these treatments for 80% of hemophiliacs globally, particularly in developing countries.

Purpose of the Study:

  • To evaluate the feasibility and impact of local production of low- to intermediate-purity factor concentrates in developing countries.
  • To explore the economic viability and benefits of establishing local plasma fractionation facilities.

Main Methods:

  • Review of experiences in South Africa, Thailand, Cuba, and Brazil regarding local factor concentrate production.
  • Analysis of the infrastructure requirements and cost-effectiveness of basic plasma fractionation.

Main Results:

Related Experiment Videos

  • Local production yields economical factor concentrates compared to commercial products, drastically improving hemophilia care.
  • Accessible, low-cost concentrates facilitate wider treatment availability and home therapy.
  • Plasma fractionation plants also produce albumin and immunoglobulins, generating revenue to subsidize hemophilia care and improve transfusion services.

Conclusions:

  • Local production of intermediate-purity factor concentrates is essential for developing countries.
  • Well-organized transfusion services are crucial for collecting sufficient plasma for fractionation.
  • This strategy improves hemophilia care and benefits patients with other transfusion-dependent diseases.