Potent beta-lactam inhibitors of human cytomegalovirus protease
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Updated: Oct 26, 2026

Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods
Published on: December 21, 2019
C Yoakim1, W W Ogilvie, D R Cameron
1Bio-Méga Research Division, Boehringer Ingelheim (Canada), Laval, Québec. cyoakim@bio-mega.boehringer-ingelheim.ca
Abstract:
A series of novel monobactam inhibitors of human cytomegalovirus (HCMV) protease has been described that possess a heterocyclic thiomethyl side chain at C-4. Changes to the heterocycle did not significantly change the inhibitory activity of these compounds in an enzymatic assay, although improvements in solubility and cell culture activity were noted. A number of permutations between C-4 substitutions and N-1 derivatives led to the identification of several beta-lactams with antiviral activity in a plaque reduction assay. N-methyl thiotetrazole-containing compounds were found to be the most potent inhibitors in the enzymatic assay.
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