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Aryl phosphate derivatives of 3'-deoxythymidine are not potent anti-human immunodeficiency virus agents
R Vig1, T K Venkatachalam, S T Jan
1Drug Discovery Program, Hughes Institute, St Paul, Minnesota 55113, USA.
Antiviral Chemistry & Chemotherapy
|January 6, 1999
Abstract:
Aryl phosphate derivatives of 3'-deoxythymidine (3dT), albeit more active than 3dT in thymidine kinase (TK)-deficient cells, are not potent anti-human immunodeficiency virus (HIV) agents and are capable of inhibiting HIV replication only at micromolar concentrations.