Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Improved nitric oxide detection using 2,3-diaminonaphthalene and its application to the evaluation of novel nitric oxide synthase inhibitors.

Biological & pharmaceutical bulletin·1999

Same author

Brain tumors in surgical neuropathology of intractable epilepsies, with special reference to cerebral dysplasias.

Brain tumor pathology·1999

Same author

Influence of speech-coding strategy on cortical activity in cochlear implant users: a positron emission tomographic study.

Acta oto-laryngologica·1998

Same author

Differential induction by methyl jasmonate of genes encoding ornithine decarboxylase and other enzymes involved in nicotine biosynthesis in tobacco cell cultures.

Plant molecular biology·1998

Same author

Increased intestinal glucose absorption and postprandial hyperglycaemia at the early step of glucose intolerance in Otsuka Long-Evans Tokushima Fatty rats.

Diabetologia·1998

Same author

Direct evidence of NO production in rat hippocampus and cortex using a new fluorescent indicator: DAF-2 DA.

Neuroreport·1998

Search research articles

Related Experiment Video

Updated: Jul 17, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Anaplastic large-cell lymphoma of null-cell type with multiple bone involvement

K Suzukawa¹, H Kojima, N Mori

¹Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.

Annals of Hematology

|January 6, 1999

Summary

This case report details a young man with anaplastic large cell lymphoma (ALCL) of the null-cell type, presenting with severe neurological deficits due to spinal involvement. Despite aggressive treatment, the patient experienced bone marrow relapse and succumbed to the disease.

More Related Videos

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Related Experiment Videos

Last Updated: Jul 17, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Area of Science:

Hematology
Oncology
Pathology

Background:

Anaplastic large cell lymphoma (ALCL) is a distinct type of non-Hodgkin lymphoma.
Null-cell type ALCL is characterized by specific immunophenotypic markers.
Bone involvement in ALCL can lead to significant clinical complications.

Observation:

A 21-year-old male presented with incomplete paraplegia and incontinence.
Imaging revealed extensive bone lesions and para-aortic lymphadenopathy.
Lumbar spine biopsy showed a proliferation of CD30+, EMA+, vimentin+, and p80NPM/ALK+ anaplastic large cells.

Findings:

The patient was diagnosed with null-cell type ALCL with widespread bone metastasis.
Immunohistochemistry confirmed the ALCL phenotype, excluding Epstein-Barr virus association.
Despite multi-modal therapy including chemotherapy, radiation, and stem cell transplant, bone marrow infiltration occurred.

Implications:

This case highlights the aggressive nature of null-cell type ALCL, even in young patients.
Rapid progression and treatment resistance underscore the challenges in managing disseminated ALCL.
Further research into novel therapeutic strategies for refractory ALCL is warranted.