Related Experiment Video
Updated: Jul 17, 2026
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Anaplastic large-cell lymphoma of null-cell type with multiple bone involvement
1Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
This case report details a young man with anaplastic large cell lymphoma (ALCL) of the null-cell type, presenting with severe neurological deficits due to spinal involvement. Despite aggressive treatment, the patient experienced bone marrow relapse and succumbed to the disease.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Anaplastic large cell lymphoma (ALCL) is a distinct type of non-Hodgkin lymphoma.
- Null-cell type ALCL is characterized by specific immunophenotypic markers.
- Bone involvement in ALCL can lead to significant clinical complications.
Observation:
- A 21-year-old male presented with incomplete paraplegia and incontinence.
- Imaging revealed extensive bone lesions and para-aortic lymphadenopathy.
- Lumbar spine biopsy showed a proliferation of CD30+, EMA+, vimentin+, and p80NPM/ALK+ anaplastic large cells.
Findings:
- The patient was diagnosed with null-cell type ALCL with widespread bone metastasis.
- Immunohistochemistry confirmed the ALCL phenotype, excluding Epstein-Barr virus association.
- Despite multi-modal therapy including chemotherapy, radiation, and stem cell transplant, bone marrow infiltration occurred.
Implications:
- This case highlights the aggressive nature of null-cell type ALCL, even in young patients.
- Rapid progression and treatment resistance underscore the challenges in managing disseminated ALCL.
- Further research into novel therapeutic strategies for refractory ALCL is warranted.
More Related Videos
05:32Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
Published on: January 7, 2019
07:17Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
Published on: August 23, 2024