Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fetal development in alloxan-treated rats

M Palomar-Morales1, L A Baiza, L Verdín-Terán

  • 1Medical Research Unit in Metabolic Diseases, National Medical Center, Mexican Institute fo Social Security, D.F.

Reproductive Toxicology (Elmsford, N.Y.)
|January 6, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beetle (Ulomoides dermestoides) fat improves diabetes: effect on liver and pancreatic architecture and on PPARγ expression.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2018
Same author

Cucurbita ficifolia (Cucurbitaceae) modulates inflammatory cytokines and IFN-γ in obese mice.

Canadian journal of physiology and pharmacology·2016
Same author

Interactions of a standardized flavonoid fraction from Tilia americana with Serotoninergic drugs in elevated plus maze.

Journal of ethnopharmacology·2015
Same author

Overview of environmental and occupational vanadium exposure and associated health outcomes: an article based on a presentation at the 8th International Symposium on Vanadium Chemistry, Biological Chemistry, and Toxicology, Washington DC, August 15-18, 2012.

Journal of immunotoxicology·2013
Same author

Effect of an aqueous extract of Cucurbita ficifolia Bouché on the glutathione redox cycle in mice with STZ-induced diabetes.

Journal of ethnopharmacology·2012
Same author

Effect of varying dose and administration of streptozotocin on blood sugar in male CD1 mice.

Proceedings of the Western Pharmacology Society·2012

Alloxan

Area of Science:

  • Toxicology
  • Developmental Biology
  • Reproductive Science

Background:

  • Alloxan is a chemical agent used to induce experimental diabetes.
  • Understanding its effects on pregnancy is crucial for reproductive toxicology research.

Purpose of the Study:

  • To evaluate the impact of alloxan administration on embryo and fetal development in pregnant rats.
  • To determine optimal dosing and timing for inducing gestational diabetes in research models.

Main Methods:

  • Pregnant rats were administered alloxan intraperitoneally at varying doses (80-150 mg/kg) on Day 0 or Day 4 of gestation.
  • Effects on maternal health, hyperglycemia, embryonic development, and malformations were assessed.

Main Results:

Related Experiment Videos

  • Lower alloxan doses (80-100 mg/kg) resulted in minimal hyperglycemia and low malformation rates.
  • Higher doses (110-150 mg/kg) induced severe hyperglycemia, maternal/embryonic death.
  • Administration on Day 4 caused resorption nodules and delayed embryonic growth.

    • Conclusions:

    • Alloxan can induce developmental toxicity and embryonic death in a dose-dependent manner.
    • Administering alloxan on Day 4 of gestation is recommended for studying diabetes-gestation interactions.
    • This timing allows for the induction of gestational diabetes without immediate maternal toxicity.