Related Experiment Video
Updated: Aug 10, 2026

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
Published on: May 13, 2019
Double patch closure of ventricular septal defect with increased pulmonary vascular resistance
W M Novick1, A T Gurbuz, D C Watson
1Le Bonheur Children's Medical Center, University of Tennessee, Memphis, USA. ichfno@aol.com
Insights
A novel flap valve double VSD patch effectively reduces complications in children undergoing large ventricular septal defect (VSD) repair. This technique lowers postoperative morbidity and mortality in pediatric patients with elevated pulmonary vascular resistance.
Area of Science:
- Pediatric Cardiac Surgery
- Congenital Heart Disease
- Cardiovascular Surgery
Background:
- Large ventricular septal defects (VSD) in children with elevated pulmonary vascular resistance carry high risks of morbidity and mortality.
- Pulmonary hypertensive episodes are a significant postoperative concern.
- A new surgical approach was developed to mitigate these risks.
Purpose of the Study:
- To evaluate the safety and efficacy of a fenestrated flap valve double VSD patch.
- To reduce morbidity and mortality in pediatric VSD closure with elevated pulmonary vascular resistance.
Main Methods:
- Eighteen children with large VSDs and elevated pulmonary vascular resistance underwent repair using a fenestrated flap valve double VSD patch.
- The procedure involved moderately hypothermic cardiopulmonary bypass and cardioplegic arrest.
- A unique double patch technique with a fenestrated primary patch was employed.
Main Results:
- All patients survived the surgery and were weaned from support within 48 hours.
- Postoperative pulmonary artery pressures were significantly reduced compared to preoperative levels.
- One late mortality occurred 9 months postoperatively.
Conclusions:
- The flap valve double VSD patch is a safe and effective method for closing large VSDs in children with elevated pulmonary vascular resistance.
- This technique significantly lowers postoperative morbidity and mortality.
Background:
Closure of a large ventricular septal defect (VSD) in children with elevated pulmonary vascular resistance is associated with significant morbidity and mortality. Pulmonary hypertensive episodes continue to be a major cause of postoperative morbidity and mortality. We designed a fenestrated flap valve double VSD patch in an effort to decrease the morbidity and mortality associated with the closure of a large VSD with elevated pulmonary vascular resistance.
Methods:
Eighteen children (mean age, 5.7 years) with a large VSD and elevated pulmonary vascular resistance (mean, 11.4 Wood units) underwent double patch VSD closure using moderately hypothermic cardiopulmonary bypass and cardioplegic arrest. The routine VSD patch was fenestrated (4 to 6 mm) and on the left ventricular side of the patch, a second, smaller patch was attached to the fenestration along its superior margin before closure of the VSD.
Results:
All children survived operation and were weaned from inotropic and ventilator support within 48 hours postoperatively. Postoperative pulmonary artery pressures were significantly lower than preoperative values. One child died 9 months postoperatively.
Conclusions:
Closure of a large VSD in children with elevated pulmonary vascular resistance can be performed with low morbidity and mortality when a flap valve double VSD patch is used.
Related Concept Videos
Mitral Stenosis I: Introduction
Mitral Stenosis III: Medical Management
Pulmonary Edema II: Pathophysiology

