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Evolutionary epidemiology and manic depression

D R Wilson1

  • 1The Lewis Centre, Cincinnati, OH 45237, USA. wilson@fuse.net

The British Journal of Medical Psychology
|January 6, 1999
PubMed
Summary
This summary is machine-generated.

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Genes linked to manic depression may have provided evolutionary advantages, challenging the view that disease genes are always maladaptive. This study explores evolutionary epidemiology and manic depression

Area of Science:

  • Evolutionary biology
  • Genetics
  • Psychiatry

Background:

  • Medical genetics often assumes disease-associated genes are maladaptive.
  • Evolutionary epidemiology offers a new framework for understanding disease prevalence.
  • Manic depression is a major public health concern with complex genetic underpinnings.

Purpose of the Study:

  • To introduce the emerging field of evolutionary epidemiology.
  • To examine manic depression through the lens of evolutionary epidemiology.
  • To propose a new model for understanding the genetic and evolutionary basis of manic depression.

Main Methods:

  • Reformulating epidemiological prevalence as evolutionary frequency rates.
  • Analyzing the medical genetics of manic depression.

Related Experiment Videos

  • Developing a paleoneuropsychiatric model for manic depression.

    • Main Results:

    • Genes associated with manic depression may represent an adaptive polymorphism.
    • These genes likely conferred selective advantages in human phylogeny.
    • A proposed model links manic depression to behavioral strategies favored in social competition.

    Conclusions:

    • Manic depression's genetic basis may be rooted in evolutionary advantages, not just maladaptation.
    • Understanding manic depression requires considering its phylogenetic context and potential benefits.
    • This perspective may influence clinical practices and ethical considerations in mental health care.