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Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertension
P C Guimarães1, P Puech-Leão, B M Netto
1Vascular Surgery Service, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brazil. pguimara@uol.com.br
Objective:
To analyze variations in leukocyte count and thromboxane B2 production in the femoral vein of patients with chronic venous hypertension (CVH).
Design:
Prospective clinical study, controlled, non randomized and open.
Location:
Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, referral center, university hospital.
Participants:
15 patients with recurring stasis ulcer were analyzed, selected randomly from the venous diseases outpatient center, and 4 without lower limb venous alterations were also analyzed.
Intervention:
Blood samples from the femoral and brachial veins were drawn following supine and 45 degrees reverse Trendelenburg.
Main Outcomes Measures:
Direct leukocyte count and analysis of the thromboxane B2 with enzyme linked immunosorbent assay test.
Results:
After 30 minutes in reverse Trendelenburg, patients with CVH showed a leukocyte count reduced by +/- 27% (p = 0.02) and thromboxane B2 levels increased by +/- 158% (p = 0.02).
Conclusions:
We suggest that future studies of medications for stasis ulcers include their effects on leukocyte entrapment and thromboxane B2 production in the lower limb venous system.