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Recent approaches in insulin delivery

A Trehan1, A Ali

  • 1Faculty of Pharmacy, Hamdard University, New Delhi, India.

Drug Development and Industrial Pharmacy
|January 7, 1999
PubMed
Summary
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Human insulin development improved diabetes management. Novel delivery systems overcome injection barriers, offering convenient and regulated insulin administration for patients.

Area of Science:

  • Endocrinology
  • Pharmaceutical Sciences
  • Biotechnology

Background:

  • Insulin, discovered in 1921, is crucial for diabetes mellitus management.
  • Early animal-sourced insulins posed challenges, driving the development of human insulin via transpeptidation and biosynthesis.
  • Patient-reported issues like needle phobia and injection stress spurred research into alternative insulin delivery methods.

Purpose of the Study:

  • To detail the evolution of human insulin production.
  • To explore diverse insulin delivery routes beyond injections.
  • To review advancements in insulin delivery devices and systems.

Main Methods:

  • Review of historical development of insulin.
  • Analysis of various non-injectable insulin delivery routes (oral, nasal, buccal, rectal, pulmonary).

Related Experiment Videos

  • Examination of innovative insulin delivery devices and regulated systems.

    • Main Results:

    • Human insulin production methods have advanced significantly.
    • Multiple alternative delivery routes for insulin have been investigated and developed.
    • New devices offer regulated, safe, and convenient insulin delivery, including bioresponsive systems.

    Conclusions:

    • The journey of insulin from animal sources to biosynthetic human insulin has been transformative.
    • Alternative delivery routes and advanced devices are crucial for improving patient adherence and quality of life in diabetes care.
    • Future innovations focus on intelligent, self-regulated insulin delivery systems.