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The effect of structural changes on swelling kinetics of polybasic/hydrophobic pH-sensitive hydrogels
1Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Iran.
Drug Development and Industrial Pharmacy
|January 7, 1999
Abstract:
The effect of pendent side-chain length and crosslinking agent concentration in methyl methacrylate/dimethylaminoethyl methacrylate as a polybasic/hydrophobic pH-sensitive hydrogel was studied. Increasing both side-chain length and crosslinking agent concentration decreased the sharpness of response to pH and water-uptake capacity of the polymer. A case-II water transport mechanism and a nonlinear swelling kinetic was observed for the homologues of this hydrogel.