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Controlled drug delivery by biodegradable poly(ester) devices: different preparative approaches

R Jain1, N H Shah, A W Malick

  • 1Department of Applied Pharmaceutical Sciences, The University of Rhode Island, Kingston 02881, USA. jainr@nanosys.com

Drug Development and Industrial Pharmacy
|January 7, 1999
PubMed
Summary

Biodegradable polymers like poly(lactide-co-glycolide) (PLGA) are crucial for advanced drug delivery systems. This review details PLGA device preparation, focusing on microparticle fabrication for enhanced therapeutic applications.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Biodegradable polymers have been researched for drug delivery since the introduction of bioresorbable sutures.
  • Thermoplastic aliphatic poly(esters), including poly(lactide) (PLA), poly(glycolide) (PGA), and their copolymer poly(lactide-co-glycolide) (PLGA), exhibit excellent biocompatibility and biodegradability.
  • These polymers offer mechanical strength and are FDA-approved for drug delivery applications.

Purpose of the Study:

  • To review preparation techniques for drug-loaded PLGA devices.
  • To emphasize methods for preparing PLGA microparticles for drug delivery.
  • To discuss related biodegradable polyesters.

Main Methods:

  • Literature review of preparation techniques for PLGA drug delivery devices.

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  • Focus on microparticle fabrication methods.
  • Discussion of formulation strategies for various drug classes.

    • Main Results:

    • PLGA polymers are versatile for formulating devices carrying vaccines, peptides, proteins, and micromolecules.
    • Various preparation techniques exist for drug-loaded PLGA devices, with microparticles being a key focus.
    • PLGA's properties make it suitable for controlled release applications.

    Conclusions:

    • PLGA is a highly effective and FDA-approved biodegradable polymer for advanced drug delivery systems.
    • Microparticle preparation techniques are critical for optimizing drug loading and release profiles.
    • Further research into PLGA and related polyesters can advance therapeutic applications.